DDX46

Across TCGA pan-cancer cohorts, DDX46 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DDX46’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where DDX46 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX46 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and STAD are the cancer types where DDX46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	III,IV	+1.058	<.001	9	view →
THCA	Male	III,IV	−0.669	<.001	9	view →
STAD	All	II,III,IV	+0.627	<.001	9	view →
HNSC	All	II,III,IV	+0.406	<.001	9	view →
BRCA	All	II,III,IV	+0.327	<.001	8	view →
BLCA	All	All	+0.318	.008	6	view →
CHOL	Female	All	+1.883	<.001	5	view →
KICH	All	All	−0.890	<.001	5	view →
COAD	Male	All	+0.411	<.001	4	view →
LUSC	Male	All	+0.342	<.001	4	view →
LUAD	All	All	+0.282	.001	3	view →
READ	All	III,IV	+0.905	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DDX46–LIHC

Open the LIHC breakdown →