DDX4

Across TCGA cell cohorts, DDX4 mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX4-associated genes across cancer lineages are HMGXB4, QPRT, and FAM149A. Each is linked with DDX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX4-to-partner and partner-to-DDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by DDX4-low versus DDX4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX4→partner) and Y-score (partner→DDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HMGXB4 →	+0.611	+3.364	.001	.002	3	1
LARGE_INTESTINE	QPRT →	-2.710	-3.278	<.001	.006	3	1
LARGE_INTESTINE	FAM149A →	+1.423	+3.364	<.001	.002	3	1
LARGE_INTESTINE	C12orf57 →	+0.911	+3.364	.001	.002	3	1
LARGE_INTESTINE	TBX18 →	+1.476	+3.537	<.001	.001	3	1
LARGE_INTESTINE	KDSR →	+0.847	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

HMGXB4 by DDX4 expression — LARGE_INTESTINE

Explore this box plot interactively →