DDX4

Across TCGA pan-cancer cohorts, DDX4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DDX4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DDX4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX4 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

LUAD, KICH, and LIHC are the cancer types where DDX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.096	.004	4	view →
KICH	Male	II,III,IV	−0.073	.003	4	view →
LIHC	All	All	+0.025	<.001	4	view →
CHOL	All	All	+0.075	.017	2	view →
KIRP	Female	II,III,IV	−0.054	.044	2	view →
BLCA	Female	All	+0.033	.043	2	view →
KIRC	Male	All	−0.020	<.001	2	view →
LUSC	All	All	+0.067	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

DDX4–LUAD

Open the LUAD breakdown →