Across TCGA patient cohorts, DDX3X mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX3X-associated genes across cancer lineages are GAPDH, eIF4E, and PDCD4. Each is linked with DDX3X in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX3X-to-partner and partner-to-DDX3X results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX3X→partner) and Y-score (partner→DDX3X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.520	+2.321	.026	.033	3	2
UCEC	eIF4E →	+0.129	+1.047	.022	.018	3	2
UCEC	PDCD4 →	-0.426	-1.423	<.001	.004	3	2
UCEC	VHL →	-0.469	-1.201	.009	.025	3	2
UCEC	ASNS →	+0.301	+1.353	.001	.013	3	2
UCEC	ATM →	-0.352	-1.834	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration

DDX3X survival (RNA) · tumor vs normal (RNA) · all DDX3X data types