DDIT4L

Across TCGA cell cohorts, DDIT4L mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDIT4L-associated genes across cancer lineages are DRD3, CD300H, and MMP27. Each is linked with DDIT4L in more than 1 cancer types. Because this analysis shows association rather than direction, both DDIT4L-to-partner and partner-to-DDIT4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRD3 grouped by DDIT4L-low versus DDIT4L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDIT4L→partner) and Y-score (partner→DDIT4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DRD3 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.052	+5.415	<.001	.004	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1
BLOOD_Lymphoma	SOX14 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	USP17L11 →	+0.025	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

DRD3 by DDIT4L expression — LARGE_INTESTINE

Explore this box plot interactively →