DDIT4L

Across TCGA pan-cancer cohorts, DDIT4L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DDIT4L’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DDIT4L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDIT4L is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

LUAD, THCA, and HNSC are the cancer types where DDIT4L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDIT4L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+1.948	<.001	9	view →
THCA	Male	All	−1.056	<.001	9	view →
HNSC	Male	All	−2.180	<.001	8	view →
BRCA	All	III,IV	−1.204	<.001	6	view →
BLCA	Male	All	−0.961	.003	6	view →
KICH	All	All	−1.785	.001	4	view →
READ	All	All	−0.977	.014	4	view →
KIRP	Male	All	−1.359	.002	3	view →
UCEC	All	All	+1.063	.006	2	view →
PRAD	All	All	−0.996	<.001	2	view →
KIRC	Male	II,III,IV	−0.860	.027	2	view →
LIHC	Male	All	+0.187	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DDIT4L–LUAD

Open the LUAD breakdown →