DDIT4L

Across TCGA pan-cancer cohorts, DDIT4L RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DDIT4L data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher DDIT4L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDIT4L expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

UVM, KIRC, and ACC are the cancer types where DDIT4L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.338	0.766	<.001	110	view →
KIRC	OS	Median	All	0.864	0.747	<.001	75	view →
ACC	OS	Median	IV	0.800	0.303	.001	61	view →
LGG	DFS	Median	All	0.315	0.481	<.001	54	view →
THCA	OS	Median	All	0.958	1.000	<.001	52	view →
STAD	OS	Median	III,IV	0.554	0.695	.005	51	view →
KICH	OS	Median	II,III,IV	0.635	1.000	.001	37	view →
UCEC	OS	Median	All	0.828	0.558	.001	36	view →
GBM	OS	Median	All	0.286	0.520	.003	30	view →
OV	OS	Median	IV	0.650	0.828	.011	20	view →
LIHC	OS	Quartile	II,III,IV	0.524	0.772	.013	19	view →
SKCM	DFS	Tertile	All	0.692	0.544	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DDIT4L–UVM (DFS)

Open the UVM breakdown →