DDI2

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DDI2 mutation is significantly associated with the RNA expression of many other genes, with 635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDI2-associated genes across cancer lineages are RN7SL248P, MIR4780, and RN7SL656P. Each is linked with DDI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDI2-to-partner and partner-to-DDI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDI2→partner) and Y-score (partner→DDI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRN7SL248P →+0.114+4.137<.001<.00132
BRCAMIR4780 →+0.458+8.471<.001.00532
BLCARN7SL656P →+0.164+6.444<.001.00132
UCECMIR3612 →+0.242+2.602.007.00632
UCECCOX6CP7 →+0.159+2.462.006.00432
STADRNU6-505P →+0.391+5.366<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 635 associations by consensus.

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