Across TCGA pan-cancer cohorts, DDI2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DDI2’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DDI2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDI2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
BLCA, KIRC, and STAD are the cancer types where DDI2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDI2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.