DDHD2

Across TCGA cell cohorts, DDHD2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDHD2-associated genes across cancer lineages are BPIFB6, HTR1E, and S100G. Each is linked with DDHD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDHD2-to-partner and partner-to-DDHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by DDHD2-low versus DDHD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDHD2→partner) and Y-score (partner→DDHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	HTR1E →	+0.085	+3.930	<.001	.003	3	1
LARGE_INTESTINE	S100G →	+1.647	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	UTF1 →	+0.022	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OR2J3 →	+0.040	+3.920	<.001	.005	3	1
LARGE_INTESTINE	INSRR →	+0.037	+3.584	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

BPIFB6 by DDHD2 expression — LARGE_INTESTINE

Explore this box plot interactively →