DDHD2

Across TCGA pan-cancer cohorts, DDHD2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DDHD2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DDHD2 RNA is repressed in tumor relative to normal tissue. In most cancer types DDHD2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, CHOL, and KICH are the cancer types where DDHD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDHD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.627	<.001	8	view →
CHOL	All	All	+1.508	<.001	5	view →
KICH	All	All	−0.529	<.001	5	view →
HNSC	All	All	+0.360	.007	5	view →
BRCA	All	All	−0.284	.004	3	view →
LUAD	Female	II,III,IV	−0.443	.005	2	view →
LUSC	All	II,III,IV	+0.358	.030	2	view →
LIHC	All	All	+0.350	.001	2	view →
PRAD	All	All	−0.314	.006	2	view →
READ	Female	All	−0.782	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DDHD2–THCA

Open the THCA breakdown →