DCUN1D4

Across TCGA patient cohorts, DCUN1D4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCUN1D4-associated genes across cancer lineages are ASNS, Cyclin-B1, and 14-3-3_beta. Each is linked with DCUN1D4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCUN1D4-to-partner and partner-to-DCUN1D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DCUN1D4-low versus DCUN1D4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCUN1D4→partner) and Y-score (partner→DCUN1D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.396	+2.115	<.001	.016	3	2
UCEC	Cyclin-B1 →	+0.618	+2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.072	-1.780	.026	.024	3	1
UCEC	EGFR_pY1068 →	-0.193	-2.222	.017	.009	3	1
UCEC	eIF4E →	+0.179	+3.598	.008	.001	3	1
UCEC	A-Raf_pS299 →	-0.112	-2.169	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ASNS by DCUN1D4 expression — UCEC

Explore this box plot interactively →