DCUN1D4

Across TCGA pan-cancer cohorts, DCUN1D4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DCUN1D4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DCUN1D4 RNA is repressed in tumor relative to normal tissue. In most cancer types DCUN1D4 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where DCUN1D4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCUN1D4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.028	<.001	10	view →
KIRC	All	All	+0.328	<.001	10	view →
LIHC	Male	All	+0.657	<.001	9	view →
BLCA	Male	All	−0.884	<.001	8	view →
KICH	All	All	−0.725	<.001	7	view →
HNSC	All	III,IV	+0.510	<.001	7	view →
CHOL	All	All	+0.622	<.001	3	view →
PRAD	All	All	−0.526	<.001	2	view →
UCEC	All	All	−0.396	.016	2	view →
BRCA	Female	All	−0.229	.001	2	view →
LUAD	All	All	+0.191	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DCUN1D4–THCA

Open the THCA breakdown →