DCSTAMP

Across TCGA cell cohorts, DCSTAMP mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCSTAMP-associated genes across cancer lineages are SPATA31D3, SKOR2, and PRAMEF4. Each is linked with DCSTAMP in more than 1 cancer types. Because this analysis shows association rather than direction, both DCSTAMP-to-partner and partner-to-DCSTAMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D3 grouped by DCSTAMP-low versus DCSTAMP-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCSTAMP→partner) and Y-score (partner→DCSTAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPATA31D3 →	+0.013	+5.285	<.001	.003	3	1
STOMACH	SKOR2 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	PRAMEF4 →	+0.006	+5.285	<.001	.003	3	1
LARGE_INTESTINE	DHDH →	+0.569	+3.212	.006	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	1
LARGE_INTESTINE	ZNF7 →	+0.639	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

SPATA31D3 by DCSTAMP expression — STOMACH

Explore this box plot interactively →