DCSTAMP

Across TCGA pan-cancer cohorts, DCSTAMP RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DCSTAMP data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher DCSTAMP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DCSTAMP expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

UVM, ACC, and CESC are the cancer types where DCSTAMP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.414	0.763	<.001	116	view →
ACC	OS	Median	II,III,IV	0.754	0.939	<.001	99	view →
CESC	DFS	Median	II,III,IV	0.882	0.667	.001	62	view →
SKCM	OS	Tertile	All	0.440	0.250	<.001	48	view →
LGG	OS	Median	All	0.750	0.859	<.001	43	view →
LUAD	DFS	Median	All	0.836	0.742	.002	42	view →
LAML	DFS	Median	All	0.213	0.544	<.001	42	view →
BLCA	DFS	Tertile	All	0.233	0.429	.007	35	view →
THYM	DFS	Tertile	All	0.757	0.954	.003	35	view →
GBM	OS	Median	All	0.318	0.497	<.001	35	view →
OV	DFS	Tertile	All	0.625	0.507	.006	20	view →
DLBC	DFS	Tertile	All	0.937	0.539	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DCSTAMP–UVM (OS)

Open the UVM breakdown →