DCSTAMP

Across TCGA pan-cancer cohorts, DCSTAMP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DCSTAMP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DCSTAMP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DCSTAMP is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where DCSTAMP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCSTAMP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	+7.666	<.001	11	view →
KIRC	Male	II,III,IV	+0.554	<.001	11	view →
HNSC	All	II,III,IV	+0.462	.003	11	view →
COAD	Male	II,III,IV	+0.587	<.001	10	view →
LUSC	Female	All	−2.212	<.001	8	view →
LUAD	Female	All	−1.650	<.001	8	view →
STAD	All	II,III,IV	+0.702	<.001	7	view →
KIRP	Male	All	+0.873	<.001	6	view →
BRCA	Female	II,III,IV	+0.506	<.001	6	view →
LIHC	All	II,III,IV	+0.230	.003	6	view →
UCEC	All	All	+0.289	.040	2	view →
READ	All	All	+0.438	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DCSTAMP–THCA

Open the THCA breakdown →