DCAF5

Across TCGA cell cohorts, DCAF5 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DCAF5-associated genes across cancer lineages are KIF2B, LEUTX, and ACSM2B. Each is linked with DCAF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF5-to-partner and partner-to-DCAF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF2B grouped by DCAF5-low versus DCAF5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF5→partner) and Y-score (partner→DCAF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KIF2B →	+0.047	+4.981	<.001	.008	3	1
CNS	LEUTX →	+0.226	+5.321	<.001	.005	3	1
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
LARGE_INTESTINE	KLHDC7B →	+0.561	+3.485	.001	.004	3	1
LARGE_INTESTINE	SCN2A →	+0.546	+3.658	<.001	.003	3	1
LARGE_INTESTINE	TBC1D3 →	+0.043	+2.688	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

KIF2B by DCAF5 expression — CNS

Explore this box plot interactively →