DCAF5

Across TCGA pan-cancer cohorts, DCAF5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DCAF5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DCAF5 RNA is repressed in tumor relative to normal tissue. In most cancer types DCAF5 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where DCAF5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCAF5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.340	<.001	8	view →
HNSC	Female	All	+0.669	.001	7	view →
LIHC	All	All	+0.314	.003	6	view →
COAD	All	All	−0.309	<.001	5	view →
BRCA	Female	All	−0.192	.002	4	view →
LUSC	All	All	−0.205	.015	3	view →
CHOL	All	All	+0.752	.005	2	view →
READ	All	All	−0.509	.008	2	view →
LUAD	All	All	−0.182	.019	2	view →
KICH	All	All	−0.293	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DCAF5–THCA

Open the THCA breakdown →