DCAF10

Across TCGA patient cohorts, DCAF10 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF10-associated genes across cancer lineages are Caspase-8, Cyclin-E2, and 14-3-3_beta. Each is linked with DCAF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF10-to-partner and partner-to-DCAF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by DCAF10-low versus DCAF10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF10→partner) and Y-score (partner→DCAF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.241	-2.673	.009	.005	3	2
UCEC	Cyclin-E2 →	+0.170	+2.710	.006	.003	3	2
UCEC	14-3-3_beta →	-0.086	-1.847	.020	.049	3	1
UCEC	eIF4E →	+0.233	+2.920	.002	<.001	3	1
UCEC	eIF4G →	+0.273	+2.115	.016	.017	3	1
UCEC	A-Raf_pS299 →	-0.193	-2.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-8 by DCAF10 expression — UCEC

Explore this box plot interactively →