DCAF10

Across TCGA pan-cancer cohorts, DCAF10 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DCAF10’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DCAF10 RNA is repressed in tumor relative to normal tissue. In most cancer types DCAF10 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where DCAF10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCAF10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.552	<.001	9	view →
LIHC	All	II,III,IV	+0.600	<.001	8	view →
HNSC	Male	All	+0.405	.004	7	view →
KIRC	Male	All	−0.300	<.001	7	view →
BRCA	All	II,III,IV	+0.912	<.001	6	view →
COAD	Male	IV	+0.495	.008	5	view →
CHOL	All	All	+0.762	.006	2	view →
READ	Male	All	+0.613	.021	2	view →
STAD	Male	IV	+1.110	.023	1	view →
ESCA	Female	All	+0.833	.048	1	view →
LUAD	Male	All	+0.318	.035	1	view →
LUSC	All	All	+0.231	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DCAF10–THCA

Open the THCA breakdown →