DCAF10

Across TCGA pan-cancer cohorts, DCAF10 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DCAF10 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher DCAF10 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DCAF10 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, KIRC, and CESC are the cancer types where DCAF10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.886	0.689	<.001	80	view →
KIRC	OS	Median	All	0.722	0.545	<.001	70	view →
CESC	DFS	Median	III,IV	0.180	0.785	<.001	36	view →
ACC	DFS	Quartile	All	0.224	0.891	.003	33	view →
UVM	DFS	Quartile	III,IV	0.170	0.814	.001	28	view →
MESO	DFS	Median	III,IV	0.210	0.626	.004	24	view →
GBM	DFS	Quartile	All	0.531	0.172	<.001	24	view →
BLCA	DFS	Tertile	All	0.231	0.549	.011	18	view →
THCA	OS	Median	II,III,IV	0.851	0.979	.012	13	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.479	.005	10	view →
SARC	OS	Tertile	All	0.742	0.972	.001	9	view →
LGG	OS	Quartile	All	0.727	0.906	.009	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DCAF10–BRCA (DFS)

Open the BRCA breakdown →