DBX1

Across TCGA patient cohorts, DBX1 mutation is significantly associated with the RNA expression of many other genes, with 3,094 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBX1-associated genes across cancer lineages are RNA5SP158, SLC25A5P4, and RPL36P18. Each is linked with DBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DBX1-to-partner and partner-to-DBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP158 grouped by DBX1-low versus DBX1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBX1→partner) and Y-score (partner→DBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP158 →	+0.410	+6.221	<.001	.001	3	2
LUAD	SLC25A5P4 →	+0.096	+4.990	<.001	.009	3	2
LUAD	RPL36P18 →	+0.184	+4.990	.001	.009	3	2
BRCA	TPM3P3 →	+0.133	+5.844	<.001	<.001	3	2
UCEC	INCENP →	+0.780	+2.938	<.001	<.001	3	2
UCEC	FARP1 →	+0.427	+1.858	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,094 associations by consensus.

RNA5SP158 by DBX1 expression — HNSC

Explore this box plot interactively →