Q-omics provides the consensus-scored TPM3P3 profile across patient tissues and cancer cell-line models. TPM3P3 expression is associated with patient survival in 10 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, TPM3P3 is differentially expressed in 2, with the highest sampling consensus in KIRC. Additionally, TPM3P3 RNA expression shows 6,018 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight ACC, KIRC, and STAD as cancer lineages where TPM3P3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TPM3P3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TPM3P3 survival associations across molecular data types. TPM3P3 RNA expression shows survival associations in the most cancer types (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TPM3P3 RNA expression–survival associations across cancer types. High TPM3P3 expression shows unfavorable associations in ACC, DLBC, THCA, THYM and STAD, but favorable associations in ESCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for TPM3P3 RNA expression.
This table summarizes TPM3P3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for TPM3P3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TPM3P3 shows lower tumor expression in KIRC and THCA. The KIRC box plot shows higher TPM3P3 RNA expression in normal versus tumor tissue (log2 FC = −0.013, t-test p = .014).
This table shows molecular features associated with TPM3P3 in patient tissues and cancer cell lines. In patient samples, TPM3P3 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
