DBX1

Across TCGA pan-cancer cohorts, DBX1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DBX1 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DBX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DBX1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and SCLC show a favorable association.

KIRC, LIHC, and SCLC are the cancer types where DBX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.775	0.906	.001	84	view →
LIHC	DFS	Tertile	II,III,IV	0.720	0.376	<.001	63	view →
SCLC	OS	Quartile	All	0.591	0.229	.001	59	view →
CESC	OS	Tertile	IV	0.177	0.638	.001	48	view →
BRCA	OS	Tertile	II,III,IV	0.845	0.920	.004	39	view →
UCS	DFS	Quartile	II,III,IV	0.697	0.141	.001	36	view →
LGG	DFS	Median	All	0.649	0.784	<.001	34	view →
HNSC	DFS	Quartile	All	0.779	0.664	.009	24	view →
OV	OS	Quartile	IV	0.648	0.309	.002	12	view →
THCA	DFS	Median	All	0.975	0.919	.007	11	view →
ACC	OS	Quartile	All	0.688	0.916	.018	10	view →
PAAD	DFS	Tertile	All	0.296	0.485	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

DBX1–KIRC (OS)

Open the KIRC breakdown →