DBF4B

Across TCGA patient cohorts, DBF4B mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBF4B-associated genes across cancer lineages are PDCD4, Notch1, and Caspase-7-cleavedD198. Each is linked with DBF4B in more than 2 cancer types. Because this analysis shows association rather than direction, both DBF4B-to-partner and partner-to-DBF4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by DBF4B-low versus DBF4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBF4B→partner) and Y-score (partner→DBF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.646	-3.797	<.001	<.001	3	3
LUSC	Notch1 →	+0.170	+3.027	.033	.018	3	2
COAD	Caspase-7-cleavedD198 →	+0.890	+3.708	.007	<.001	3	2
UCEC	MSH2 →	-0.293	-2.433	<.001	.018	3	2
UCEC	PCNA →	+0.318	+2.087	<.001	.005	3	2
UCEC	Rictor_pT1135 →	-0.085	-2.087	.029	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

PDCD4 by DBF4B expression — UCEC

Explore this box plot interactively →