DBF4B

Across TCGA pan-cancer cohorts, DBF4B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DBF4B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DBF4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DBF4B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where DBF4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DBF4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.264	<.001	12	view →
COAD	Female	II,III,IV	+1.090	<.001	12	view →
BLCA	Female	All	+1.190	<.001	10	view →
LUAD	Male	III,IV	+1.336	<.001	9	view →
STAD	Male	II,III,IV	+1.107	<.001	9	view →
LIHC	Female	II,III,IV	+0.897	<.001	9	view →
LUSC	Male	II,III,IV	+1.444	<.001	8	view →
KIRP	All	II,III,IV	+0.650	.002	8	view →
UCEC	All	All	+0.488	.005	6	view →
BRCA	All	II,III,IV	+0.311	<.001	6	view →
READ	All	All	+0.773	<.001	5	view →
CHOL	Male	All	+2.094	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DBF4B–HNSC

Open the HNSC breakdown →