DBF4B

Across TCGA pan-cancer cohorts, DBF4B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated DBF4B data layer compared with 4 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DBF4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DBF4B expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

ACC, KIRC, and KICH are the cancer types where DBF4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.378	0.760	<.001	111	view →
KIRC	DFS	Quartile	All	0.458	0.753	<.001	108	view →
KICH	OS	Median	All	0.723	1.000	<.001	107	view →
LIHC	DFS	Median	All	0.440	0.643	<.001	93	view →
MESO	OS	Median	All	0.439	0.641	.005	61	view →
LGG	DFS	Tertile	All	0.630	0.810	<.001	45	view →
SKCM	DFS	Tertile	II,III,IV	0.463	0.744	<.001	41	view →
KIRP	DFS	Tertile	II,III,IV	0.124	1.000	<.001	32	view →
READ	OS	Quartile	II,III,IV	0.979	0.784	.006	25	view →
UVM	OS	Quartile	III,IV	0.356	1.000	.007	23	view →
UCS	OS	Median	III,IV	0.551	0.211	.011	20	view →
BRCA	OS	Quartile	III,IV	0.965	0.845	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

DBF4B–ACC (DFS)

Open the ACC breakdown →