DBF4

Across TCGA patient cohorts, DBF4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBF4-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Chk2_pT68. Each is linked with DBF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DBF4-to-partner and partner-to-DBF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DBF4-low versus DBF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBF4→partner) and Y-score (partner→DBF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.157	+3.335	.031	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.201	-3.087	<.001	<.001	3	2
UCEC	Chk2_pT68 →	-0.135	-1.440	.036	.024	3	2
UCEC	14-3-3_beta →	-0.085	-1.673	.015	.040	3	1
UCEC	EGFR_pY1068 →	-0.291	-2.459	<.001	<.001	3	1
UCEC	ER-alpha →	-0.563	-2.584	.048	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eIF4E by DBF4 expression — UCEC

Explore this box plot interactively →