DBF4

Across TCGA pan-cancer cohorts, DBF4 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DBF4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DBF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DBF4 is over-expressed in tumor.

HNSC, BLCA, and LUAD are the cancer types where DBF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DBF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.681	<.001	12	view →
BLCA	Male	III,IV	+1.734	<.001	11	view →
LUAD	Male	II,III,IV	+1.401	<.001	11	view →
KIRP	Male	III,IV	+1.081	<.001	11	view →
KIRC	All	IV	+0.702	<.001	11	view →
KICH	Male	II,III,IV	+1.665	<.001	10	view →
STAD	Female	All	+1.890	<.001	9	view →
COAD	Male	All	+1.248	<.001	9	view →
LIHC	Male	II,III,IV	+1.035	<.001	9	view →
LUSC	Male	II,III,IV	+1.870	<.001	8	view →
UCEC	All	III,IV	+1.350	<.001	8	view →
READ	All	All	+1.043	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DBF4–HNSC

Open the HNSC breakdown →