DBF4

Across TCGA pan-cancer cohorts, DBF4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DBF4 data layer compared with 8 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DBF4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DBF4 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

KIRP, LIHC, and ACC are the cancer types where DBF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.595	0.790	<.001	177	view →
LIHC	OS	Median	All	0.422	0.590	<.001	95	view →
ACC	DFS	Median	All	0.380	0.779	<.001	82	view →
KIRC	DFS	Quartile	All	0.501	0.740	<.001	79	view →
CESC	OS	Tertile	IV	0.106	0.734	.002	64	view →
MESO	OS	Median	All	0.281	0.491	.001	61	view →
UVM	DFS	Tertile	III,IV	0.231	0.866	<.001	59	view →
LGG	OS	Median	All	0.734	0.887	<.001	53	view →
KICH	DFS	Median	All	0.700	0.969	.002	50	view →
UCS	OS	Tertile	II,III,IV	0.754	0.292	<.001	38	view →
SARC	DFS	Median	All	0.522	0.697	<.001	33	view →
PAAD	DFS	Tertile	All	0.166	0.418	<.001	31	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DBF4–KIRP (OS)

Open the KIRP breakdown →