DBF4

Across TCGA cell cohorts, DBF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,657 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DBF4-associated GO terms across cancer lineages are Positive regulation of chromosome segregation, Resolution of DNA recombination intermediates, and Immunoglobulin heavy chain V-D-J recombination. Each is linked with DBF4 in more than 18 cancer types. Because this analysis shows association rather than direction, both DBF4-to-partner and partner-to-DBF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome segregation grouped by DBF4-low versus DBF4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DBF4→partner) and Y-score (partner→DBF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of chromosome segregation →	+0.188	+1.567	<.001	<.001	3	19
BLOOD_Myeloma	Resolution of DNA recombination intermediates →	+0.147	+0.986	<.001	<.001	3	19
BREAST	Immunoglobulin heavy chain V-D-J recombination →	+0.188	+1.172	<.001	<.001	3	19
URINARY_TRACT	Protein localization to condensed chromosome →	+0.177	+0.981	<.001	.001	3	19
BONE	Positive regulation of chromosome condensation →	+0.219	+1.146	.002	.002	3	19
BLOOD_Myeloma	Spindle elongation →	+0.262	+1.169	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,657 associations by consensus.

Positive regulation of chromosome segregation by DBF4 expression — BLOOD_Myeloma

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