DBF4

Across TCGA cell cohorts, DBF4 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBF4-associated genes across cancer lineages are 5-Fluorouracil, MK-1775, and 776928. Each is linked with DBF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DBF4-to-partner and partner-to-DBF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5-Fluorouracil grouped by DBF4-low versus DBF4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBF4→partner) and Y-score (partner→DBF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	5-Fluorouracil →	+0.547	+2.991	.047	.018	3	1
LARGE_INTESTINE	MK-1775 →	+0.361	+2.868	.018	.022	3	1
LARGE_INTESTINE	776928 →	+0.662	+2.871	.026	.021	3	1
LARGE_INTESTINE	Savolitinib →	+0.447	+2.777	.011	.038	3	1
LARGE_INTESTINE	alpha-lipoic acid →	+0.396	+2.684	.005	.035	3	1
LARGE_INTESTINE	Cytarabine →	+1.094	+2.655	.003	.044	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

5-Fluorouracil by DBF4 expression — LARGE_INTESTINE

Explore this box plot interactively →