DARS-AS1

Across TCGA patient cohorts, DARS-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,777 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DARS-AS1-associated proteins across cancer lineages are LOXL2, P4HA1, and TRIT1_S455. Each is linked with DARS-AS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DARS-AS1-to-partner and partner-to-DARS-AS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DARS-AS1 versus LOXL2 in PDAC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS-AS1→partner) and Y-score (partner→DARS-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LOXL2 →	+0.578	+0.325	<.001	<.001	3	5
COAD	P4HA1 →	+0.581	+0.241	<.001	<.001	3	5
OV	TRIT1_S455 →	+0.897	+0.607	.002	<.001	3	4
COAD	KIF23 →	+0.538	+0.215	.001	.008	3	4
HNSC	MCM2_S139 →	+0.604	+0.433	<.001	.002	3	4
LSCC	MCM5 →	+0.463	+0.429	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,777 associations by consensus.

DARS-AS1 vs LOXL2 — PDAC

Explore this scatter interactively →