DARS-AS1

Across TCGA pan-cancer cohorts, DARS-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DARS-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DARS-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DARS-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and BLCA show a favorable association.

KIRP, KICH, and ACC are the cancer types where DARS-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.729	0.941	<.001	123	view →
KICH	DFS	Tertile	III,IV	0.169	1.000	<.001	99	view →
ACC	DFS	Median	All	0.273	0.642	<.001	87	view →
HNSC	DFS	Median	All	0.650	0.767	<.001	82	view →
UVM	OS	Median	All	0.402	1.000	<.001	70	view →
OV	OS	Median	All	0.742	0.634	.001	52	view →
LGG	OS	Median	All	0.741	0.897	.001	35	view →
LIHC	OS	Tertile	III,IV	0.261	0.614	.004	33	view →
MESO	OS	Median	All	0.307	0.477	.016	16	view →
BRCA	OS	Quartile	III,IV	0.537	0.797	.004	16	view →
CESC	OS	Tertile	All	0.812	0.918	.009	16	view →
BLCA	DFS	Quartile	III,IV	0.415	0.186	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DARS-AS1–KIRP (DFS)

Open the KIRP breakdown →