DARS-AS1

Across TCGA pan-cancer cohorts, DARS-AS1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DARS-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DARS-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DARS-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where DARS-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DARS-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.433	<.001	12	view →
LUAD	Female	All	+0.646	<.001	9	view →
LUSC	Female	All	+0.863	<.001	8	view →
THCA	Male	IV	−0.626	<.001	8	view →
HNSC	All	IV	+0.387	<.001	8	view →
BLCA	Male	All	+0.796	<.001	6	view →
UCEC	All	All	+0.566	<.001	6	view →
KIRP	All	All	+0.290	.001	6	view →
COAD	Male	All	+0.270	<.001	6	view →
READ	All	All	+0.328	.007	4	view →
BRCA	All	All	+0.135	.006	4	view →
CHOL	All	All	+0.493	.018	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DARS-AS1–KIRC

Open the KIRC breakdown →