DAPL1

Across TCGA patient cohorts, DAPL1 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAPL1-associated genes across cancer lineages are RNA5SP249, CTBP2P9, and ACOD1. Each is linked with DAPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAPL1-to-partner and partner-to-DAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP249 grouped by DAPL1-low versus DAPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAPL1→partner) and Y-score (partner→DAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP249 →	+0.424	+4.885	<.001	.002	3	2
SKCM	CTBP2P9 →	+0.100	+5.080	<.001	.004	3	1
UCEC	ACOD1 →	+0.322	+3.523	<.001	.005	3	1
UCEC	LINC00544 →	+0.119	+3.218	.003	.003	3	1
UCEC	IL21 →	+0.161	+3.611	.005	.001	3	1
UCEC	MIR6129 →	+0.707	+3.233	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

RNA5SP249 by DAPL1 expression — UCEC

Explore this box plot interactively →