DAPL1

Across TCGA pan-cancer cohorts, DAPL1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DAPL1 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher DAPL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DAPL1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UVM show a favorable association.

UCS, BRCA, and UVM are the cancer types where DAPL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	III,IV	0.322	0.679	.005	74	view →
BRCA	OS	Median	All	0.659	0.521	<.001	63	view →
UVM	OS	Median	II,III,IV	0.760	0.457	.009	59	view →
MESO	DFS	Tertile	All	0.490	0.295	.002	58	view →
SKCM	OS	Tertile	II,III,IV	0.656	0.831	<.001	55	view →
LGG	DFS	Median	All	0.804	0.665	<.001	51	view →
BLCA	OS	Tertile	All	0.323	0.536	.005	46	view →
LUSC	DFS	Median	II,III,IV	0.701	0.513	<.001	39	view →
HNSC	DFS	Median	IV	0.396	0.247	.005	30	view →
ACC	DFS	Median	III,IV	0.223	0.606	.003	27	view →
LUAD	OS	Tertile	All	0.468	0.258	.005	25	view →
KIRP	DFS	Tertile	All	0.977	0.866	.005	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

DAPL1–UCS (OS)

Open the UCS breakdown →