D2HGDH

Across TCGA patient cohorts, D2HGDH mutation is significantly associated with the RNA expression of many other genes, with 2,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible D2HGDH-associated genes across cancer lineages are OR52E6, CYP2C58P, and RNU6-4P. Each is linked with D2HGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both D2HGDH-to-partner and partner-to-D2HGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E6 grouped by D2HGDH-low versus D2HGDH-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (D2HGDH→partner) and Y-score (partner→D2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR52E6 →	+0.170	+4.329	<.001	.006	3	2
SKCM	CYP2C58P →	+0.025	+4.049	<.001	.007	3	2
COAD	RNU6-4P →	+0.556	+3.342	.008	.004	3	2
COAD	H2BP8 →	+0.102	+4.595	<.001	.004	3	2
COAD	RNU7-23P →	+0.334	+5.087	<.001	.002	3	2
COAD	RNA5-8SN3 →	+0.934	+4.821	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,105 associations by consensus.

OR52E6 by D2HGDH expression — SCLC

Explore this box plot interactively →