D2HGDH

Across TCGA pan-cancer cohorts, D2HGDH RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of D2HGDH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where D2HGDH RNA is repressed in tumor relative to normal tissue. In most cancer types D2HGDH is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and STAD are the cancer types where D2HGDH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in D2HGDH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.895	<.001	7	view →
THCA	All	All	−0.337	<.001	7	view →
STAD	All	II,III,IV	+0.768	<.001	6	view →
COAD	All	All	+0.567	.001	6	view →
CHOL	All	All	+1.172	<.001	5	view →
LIHC	All	All	+0.441	<.001	5	view →
KIRP	All	III,IV	−0.465	.014	4	view →
BRCA	Female	All	−0.266	.013	4	view →
HNSC	All	All	−0.318	.021	3	view →
READ	Female	All	+1.173	.005	2	view →
BLCA	Female	III,IV	+1.031	.028	1	view →
ESCA	Female	All	+0.373	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

D2HGDH–KICH

Open the KICH breakdown →