CYP8B1

Across TCGA cell cohorts, CYP8B1 mutation is significantly associated with the RNA expression of many other genes, with 625 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP8B1-associated genes across cancer lineages are OR10A5, CCDC182, and OR2D3. Each is linked with CYP8B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP8B1-to-partner and partner-to-CYP8B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A5 grouped by CYP8B1-low versus CYP8B1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP8B1→partner) and Y-score (partner→CYP8B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR10A5 →	+0.044	+4.794	<.001	.001	3	2
STOMACH	CCDC182 →	+0.025	+4.285	<.001	.007	3	1
STOMACH	OR2D3 →	+0.020	+4.432	<.001	.003	3	1
STOMACH	OR6S1 →	+0.047	+4.285	<.001	.007	3	1
LARGE_INTESTINE	RNMT →	+0.649	+3.385	.002	.004	3	1
LARGE_INTESTINE	RNF125 →	+1.264	+3.234	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 625 associations by consensus.

OR10A5 by CYP8B1 expression — STOMACH

Explore this box plot interactively →