CYP8B1

Across TCGA pan-cancer cohorts, CYP8B1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CYP8B1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CYP8B1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP8B1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and KICH are the cancer types where CYP8B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP8B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−4.270	<.001	11	view →
THCA	Female	III,IV	−0.297	<.001	11	view →
KICH	All	III,IV	−2.525	<.001	10	view →
COAD	Female	III,IV	−0.154	<.001	9	view →
LIHC	Female	II,III,IV	−5.039	<.001	8	view →
BRCA	All	All	−0.193	<.001	6	view →
HNSC	Male	II,III,IV	−0.136	.017	6	view →
CHOL	Female	All	−8.286	<.001	5	view →
BLCA	All	IV	+0.808	.018	4	view →
KIRC	All	All	−0.652	.018	2	view →
STAD	Male	All	−0.066	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CYP8B1–KIRP

Open the KIRP breakdown →