CYP7A1

Across TCGA patient cohorts, CYP7A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,082 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CYP7A1-associated GO terms across cancer lineages are ERAD pathway, Regulation of canonical Wnt signaling pathway, and Protein targeting to vacuole. Each is linked with CYP7A1 in more than 20 cancer types. Because this analysis shows association rather than direction, both CYP7A1-to-partner and partner-to-CYP7A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by CYP7A1-low versus CYP7A1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP7A1→partner) and Y-score (partner→CYP7A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ERAD pathway →	+0.095	+0.171	<.001	.006	2	21
STAD	Regulation of canonical Wnt signaling pathway →	+0.085	+0.181	<.001	.003	2	20
ESCA	Protein targeting to vacuole →	+0.081	+0.213	<.001	<.001	3	19
ESCA	Regulation of small GTPase mediated signal transduction →	+0.060	+0.169	<.001	<.001	2	20
STAD	Protein localization to lysosome →	+0.059	+0.128	<.001	.004	2	20
STAD	Vacuole organization →	+0.105	+0.195	<.001	.003	2	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,082 associations by consensus.

ERAD pathway by CYP7A1 expression — STAD

Explore this box plot interactively →