CYP7A1

Across TCGA pan-cancer cohorts, CYP7A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CYP7A1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CYP7A1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP7A1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and KICH are the cancer types where CYP7A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP7A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.165	<.001	11	view →
THCA	All	II,III,IV	−0.059	<.001	11	view →
KICH	Male	All	−0.185	<.001	9	view →
BLCA	Male	All	−0.098	.002	8	view →
BRCA	All	III,IV	−0.205	<.001	6	view →
LUSC	All	All	−0.089	<.001	5	view →
CHOL	All	All	−3.351	<.001	4	view →
UCEC	All	IV	−0.125	.001	4	view →
KIRP	All	All	−0.060	.006	3	view →
COAD	All	IV	−0.030	.007	3	view →
LIHC	Male	All	+2.083	<.001	2	view →
PAAD	Male	All	−0.125	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CYP7A1–LUAD

Open the LUAD breakdown →