CYP7A1

Across TCGA patient cohorts, CYP7A1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP7A1-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and 14-3-3_beta. Each is linked with CYP7A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP7A1-to-partner and partner-to-CYP7A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CYP7A1-low versus CYP7A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP7A1→partner) and Y-score (partner→CYP7A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.138	-1.501	.016	.015	3	2
UCEC	JNK2 →	+0.183	+1.807	.006	.004	3	2
UCEC	14-3-3_beta →	-0.101	-2.780	.003	.003	3	1
UCEC	EGFR_pY1068 →	-0.247	-2.137	.003	.001	3	1
UCEC	EGFR →	-0.176	-2.558	.001	.010	3	1
UCEC	eIF4E →	+0.167	+1.807	.020	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

JNK_pT183_Y185 by CYP7A1 expression — UCEC

Explore this box plot interactively →