CYP39A1

Across TCGA cell cohorts, CYP39A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,922 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYP39A1-associated GO terms across cancer lineages are Cholesterol catabolic process, Sterol catabolic process, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with CYP39A1 in more than 15 cancer types. Because this analysis shows association rather than direction, both CYP39A1-to-partner and partner-to-CYP39A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cholesterol catabolic process grouped by CYP39A1-low versus CYP39A1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP39A1→partner) and Y-score (partner→CYP39A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cholesterol catabolic process →	-0.420	-1.746	<.001	<.001	3	16
OESOPHAGUS	Sterol catabolic process →	-0.420	-1.746	<.001	<.001	3	16
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.089	+0.996	.005	.004	3	9
SOFT_TISSUE	Glomerular parietal epithelial cell differentiation →	+0.948	+0.786	.001	<.001	3	7
OVARY	Regulation of response to endoplasmic reticulum stress →	+0.080	+1.262	<.001	<.001	3	7
BONE	Protein transport into membrane raft →	+0.794	+0.486	.008	.005	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,922 associations by consensus.

Cholesterol catabolic process by CYP39A1 expression — OESOPHAGUS

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