CYP39A1

Across TCGA cell cohorts, CYP39A1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP39A1-associated genes across cancer lineages are GJA10, RIPPLY1, and LRIT1. Each is linked with CYP39A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP39A1-to-partner and partner-to-CYP39A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA10 grouped by CYP39A1-low versus CYP39A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP39A1→partner) and Y-score (partner→CYP39A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GJA10 →	+0.037	+3.705	<.001	.007	3	1
BLOOD_Leukemia	RIPPLY1 →	+0.029	+4.269	<.001	.002	3	1
BLOOD_Leukemia	LRIT1 →	+0.043	+4.269	<.001	.002	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1
BLOOD_Leukemia	HTR5A →	+0.039	+4.824	<.001	<.001	3	1
BLOOD_Leukemia	C16orf92 →	+0.171	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GJA10 by CYP39A1 expression — BLOOD_Leukemia

Explore this box plot interactively →