CYP2U1

Across TCGA patient cohorts, CYP2U1 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2U1-associated genes across cancer lineages are ARL5AP5, LSP1P3, and PRNT. Each is linked with CYP2U1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2U1-to-partner and partner-to-CYP2U1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL5AP5 grouped by CYP2U1-low versus CYP2U1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2U1→partner) and Y-score (partner→CYP2U1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARL5AP5 →	+0.327	+4.177	<.001	.001	3	2
UCEC	LSP1P3 →	+0.472	+3.063	<.001	.008	3	1
CESC	PRNT →	+0.024	+5.201	.001	.007	3	1
CESC	OR14I1 →	+0.351	+6.144	<.001	.001	3	1
CESC	RNU6-536P →	+0.431	+5.010	<.001	.009	3	1
CESC	RNU6-777P →	+0.454	+5.539	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ARL5AP5 by CYP2U1 expression — UCEC

Explore this box plot interactively →