CYP2U1

Across TCGA pan-cancer cohorts, CYP2U1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CYP2U1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CYP2U1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP2U1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and UCEC are the cancer types where CYP2U1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP2U1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.332	<.001	9	view →
THCA	Male	III,IV	−1.182	<.001	9	view →
UCEC	All	All	−1.943	<.001	8	view →
LUSC	All	II,III,IV	−1.157	<.001	8	view →
BLCA	Male	All	−1.277	.006	7	view →
BRCA	All	All	−1.028	<.001	6	view →
COAD	All	II,III,IV	−0.476	.001	6	view →
KICH	All	All	−0.558	<.001	4	view →
KIRC	Male	III,IV	−0.278	.036	2	view →
READ	All	All	−0.746	.040	1	view →
STAD	All	All	−0.433	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CYP2U1–LUAD

Open the LUAD breakdown →