Across TCGA patient cohorts, CYP2R1 mutation is significantly associated with the RNA expression of many other genes, with 1,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2R1-associated genes across cancer lineages are MIR548H5, KRTAP10-9, and TMEM167AP1. Each is linked with CYP2R1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2R1-to-partner and partner-to-CYP2R1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2R1→partner) and Y-score (partner→CYP2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR548H5 →	+0.717	+7.640	<.001	.009	3	3
HNSC	KRTAP10-9 →	+0.032	+3.449	<.001	.007	3	2
COAD	TMEM167AP1 →	+0.368	+4.790	<.001	.006	3	2
COAD	FAM204DP →	+0.228	+4.993	<.001	.002	3	2
HNSC	MRPS18BP1 →	+0.114	+4.286	<.001	.007	3	2
HNSC	MIR6075 →	+0.299	+3.176	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,867 associations by consensus.

Exploration

CYP2R1 survival (RNA) · tumor vs normal (RNA) · all CYP2R1 data types