CYP2D6

Across TCGA patient cohorts, CYP2D6 mutation is significantly associated with the RNA expression of many other genes, with 1,290 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2D6-associated genes across cancer lineages are RNU6-358P, MEMO1P5, and IGHVIV-44-1. Each is linked with CYP2D6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2D6-to-partner and partner-to-CYP2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-358P grouped by CYP2D6-low versus CYP2D6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2D6→partner) and Y-score (partner→CYP2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-358P →	+0.933	+4.548	<.001	.009	3	3
BLCA	MEMO1P5 →	+0.179	+6.618	<.001	.001	3	2
CESC	IGHVIV-44-1 →	+0.184	+5.201	<.001	.007	3	2
UCEC	DHFRP1 →	+0.451	+2.258	.002	.001	3	2
UCEC	XRCC6 →	+0.514	+3.861	<.001	<.001	3	2
UCEC	POLH-AS1 →	+0.536	+2.230	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,290 associations by consensus.

RNU6-358P by CYP2D6 expression — LUSC

Explore this box plot interactively →